What is SLU-PP-915?

SLU-PP-915 is a novel, synthetic small-molecule pan-agonist targeting orphaned Estrogen-Related Receptors (ERRα, ERRβ, and ERRγ). Developed by researchers at Saint Louis University, SLU-PP-915 represents an advanced second-generation chemical tool designed to overcome the first-pass metabolism limitations of earlier pan-ERR agonists. By binding the ligand-binding domain across all three orphan nuclear receptor subtypes with balanced nanomolar affinity (EC₅₀ ≈ 400 nM), a robust transcriptional program triggers that mimics the biological adaptations of acute aerobic exertion.

Batch-verified for high analytical purity at Modern Aminos, SLU-PP-915 is supplied as a high-purity dry-fill reference material for laboratory screening and cellular assays. Researchers studying mitochondrial biogenesis, oxidative phosphorylation (OXPHOS), and cardiac or metabolic tissue energetics utilize SLU-PP-915 alongside related metabolic modulators on the site, such as SLU-PP-332, GW-501516, SR-9009, and BAM15.

Chemical and Molecular Data

Compound Name	SLU-PP-915
Quantity / Formats Offered	High-Purity, Dry-Fill Capsules
Synonyms / Alt Names	SLU PP 915, Pan-ERR Agonist 915, Orally Active ERR Agonist
CAS Number	2285432-92-8
Chemical Formula	C₁₇H₁₃BFNO₃S
Molecular Weight	341.16 g/mol
Primary Target Class	Pan-ERR Nuclear Receptor Agonist (ERRα / ERRβ / ERRγ)
Receptor Potency (EC50)	ERRα: 414 nM \| ERRβ: 435 nM \| ERRγ: 378 nM
InChIKey	Protected Boron-Containing Small Molecule
SMILES Code	`Protected Synthetic Structure`

What are the Mechanisms of Action?

The biochemical pathways and cellular targets in laboratory research include:

Pan-ERR Nuclear Receptor Activation (ERRα / ERRβ / ERRγ): Research demonstrates a balanced full agonist across all three orphaned Estrogen-Related Receptor isoforms. By occupying the orphan nuclear receptor ligand-binding domain, it induces receptor-coactivator interaction with PGC-1α, driving transcription of genes regulating cellular energy production.
Mitochondrial Biogenesis & OXPHOS Gene Transcription: In skeletal muscle (C2C12) and cardiomyocyte cell lines, the upregulation of critical target genes including Pgc1a, Pdk4, Ddit4, and respiratory chain complex subunits increases basal cellular oxygen consumption rates. This shifts metabolic substrate preference toward fatty acid beta-oxidation.
TFEB-Mediated Lysosomal & Autophagic Signaling: Exposure increases the mRNA and protein expression of Transcription Factor EB (TFEB) and downstream lysosomal targets (Lamp1, Lamp2, Ctsd, p62). This enhances cellular clearance of damaged mitochondria (mitophagy) and preserves organelle quality under metabolic stress.

What do Preclinical & Academic Studies Show for SLU-PP-915?

When evaluating research efficacy and published scientific literature:

Oral Bioavailability Assessment & Exercise Mimetic Activity: Preclinical translational data archived on Patsnap Synapse document SLU-PP-915’s resistance to degradation caused by the first-pass metabolism. Furthermore, it documents the ability to activate the cellular and metabolic pathways normally triggered by physical exertion, confirming enhanced aerobic endurance and synergism with physical exertion in murine models.
TFEB & Autophagic Gene Expression in Myocytes: In vitro cell culture experiments cataloged on Biocompare verify that the addition of SLU-PP-915 significantly increases TFEB protein levels and lysosomal enzyme expression in C2C12 and ventricular myocyte cultures.
Chemical Directory & Structure Verification: Official structural characterization maintained on PubChem verifies the molecular mass (341.16 g/mol), chemical formula (C₁₇H₁₃BFNO₃S), and CAS registry number 2285432-92-8.

How does SLU-PP-915 compare to other compounds?

To evaluate nuclear receptor selectivity, pharmacokinetic profiles, and exercise-mimetic pathways, researchers compare SLU-PP-915 against alternative metabolic reference compounds available at Modern Aminos:

Compound / Reference	Primary Target Class	Core Mechanism of Action	Research Focus & Profile
SLU-PP-915	Pan-ERR Agonist (Orally Bioavailable)	Binds ERRα, ERRβ, and ERRγ (EC₅₀ ≈ 400 nM) to drive OXPHOS, TFEB autophagic pathways, and exercise mimetics	Second-generation pan-ERR agonist engineered for high survival of the first-pass metabolism, systemic exposure, and chronic metabolic/cardiac research
SLU-PP-332	First-Generation Pan-ERR Agonist	Potent ERRα/β/γ agonism (EC₅₀ = 98 nM for ERRα) driving type IIa oxidative muscle fiber switching	Pioneer pan-ERR research tool with high in vitro potency, primarily evaluated via parenteral or direct cell culture administration
GW-501516 (Cardarine)	PPARδ Selective Agonist	Recruits PGC-1α to upregulate skeletal muscle fatty acid beta-oxidation and PDK4 expression	Focuses exclusively on PPARδ nuclear receptor pathways without direct interaction with Estrogen-Related Receptors
SR-9009 (Stenabolic)	Rev-Erbα / Rev-Erbβ Agonist	Modulates circadian metabolic gene expression and enhances basal mitochondrial density	Focuses on Rev-Erb nuclear receptors and circadian metabolic control rather than ERR-driven exercise-mimetic pathways

Frequently Asked Questions (FAQs)

1. Is Modern Aminos a reliable place to buy SLU-PP-915?

Yes, Modern Aminos is a trusted vendor for high-purity research chemicals and novel metabolic reference standards. Every batch of SLU-PP-915 undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ purity, correct molecular mass (341.16 g/mol), and complete absence of unreacted synthetic precursors or heavy metals.

2. What is the structural classification and receptor target of SLU-PP-915?

SLU-PP-915 is a synthetic boron-containing small molecule that functions as a pan-agonist for Estrogen-Related Receptors (ERRs). It activates all three ERR isoforms—ERRα, ERRβ, and ERRγ—with half-maximal effective concentrations (EC₅₀) around 378–435 nM.

3. How does SLU-PP-915 differ from first-generation SLU-PP-332?

While SLU-PP-332 was the pioneer pan-ERR agonist, its chemical structure limited its oral bioavailability in systemic models. SLU-PP-915 is a chemically distinct second-generation analog optimized to survive the first-pass metabolism and demonstrates favorable pk, enabling expanded systemic and chronic research protocols.

4. What does “exercise mimetic” mean in SLU-PP-915 research?

Estrogen-Related Receptors regulate the gene network normally activated during endurance exercise. As an exercise mimetic, it stimulates ERR transcriptional targets (such as Ddit4 and Pdk4) in resting muscle cell models, inducing aerobic metabolic adaptations without requiring physical muscle contraction.

5. What role does SLU-PP-915 play in TFEB and autophagic gene induction?

SLU-PP-915 increases expression of Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy. By upregulating genes like Lamp1, Lamp2, and p62, it supports cellular recycling and mitochondrial quality control under metabolic stress.

6. How should the reference powder be solubilized for cell culture assays?

This reference powder is readily soluble in organic solvents such as dimethyl sulfoxide (DMSO) and ethanol. Concentrated DMSO stock solutions should be aliquoted and diluted into cell culture media or physiological buffers immediately prior to in vitro experimental use.

7. How does SLU-PP-915 compare to GW-501516 in nuclear receptor targeting?

GW-501516 is a selective agonist of the PPARδ nuclear receptor. SLU-PP-915 targets an entirely distinct nuclear receptor family—the Estrogen-Related Receptors (ERRα/β/γ). Both upregulate oxidative metabolism, but operate through separate transcriptional coactivator complexes.

8. What are the recommended storage parameters?

Solid reference samples should be kept tightly sealed in their original glass reagent vials at -20°C for long-term preservation. Protect from moisture, heat, and direct light exposure to maintain complete chemical stability throughout its laboratory shelf life.

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SLU-PP-915 (Pan-ERR Agonist)

SLU-PP-915 (Pan-ERR Agonist)